{"id":1525,"date":"2025-10-30T00:06:57","date_gmt":"2025-10-30T00:06:57","guid":{"rendered":"https:\/\/www-staging.archimedline.com\/?page_id=1525"},"modified":"2026-07-31T09:18:05","modified_gmt":"2026-07-31T09:18:05","slug":"peth-lc-msms-kit-whole-blood","status":"publish","type":"page","link":"https:\/\/www.archimedline.com\/en\/peth-lc-msms-kit-whole-blood\/","title":{"rendered":"A371 \u201ePEth from whole blood\u201c – IVDR"},"content":{"rendered":"\n

Why “PEth from whole blood”?<\/h2>\n\n\n\n

Designed for medium to high routine throughput, clear decision-making criteria, and seamless integration into existing LC-MS\/MS workflows.<\/p>\n\n\n\n

\n
\n

LC\u2011MS\/MS\u2011Kit for 330 Assays<\/strong><\/h3>\n\n\n\n

Scalable for routine laboratories and projects with high sample volumes.<\/p>\n<\/div>\n\n\n\n

\n

Expanded range of analytes<\/strong><\/h3>\n\n\n\n

Quantification of PEth 16:0\/18:1 and PEth 16:0\/18:2.<\/p>\n<\/div>\n\n\n\n

\n

Easy sample preparation <\/strong>
(1,5 mL tubes)<\/strong><\/h3>\n\n\n\n

Compatible with standard laboratory equipment.<\/p>\n<\/div>\n<\/div>\n\n\n\n

\n
\n

3-minute chromatographic separation<\/strong><\/h3>\n\n\n\n

With a 3.2-minute injection interval for efficient sequences.<\/p>\n<\/div>\n\n\n\n

\n

7-point calibrators & 3-point controls<\/strong><\/h3>\n\n\n\n

Reliable quantification and quality control in routine operations.<\/p>\n<\/div>\n\n\n\n

\n

Extended calibrator range<\/strong><\/h3>\n\n\n\n

Additional calibrators and controls are available.<\/p>\n<\/div>\n<\/div>\n\n\n\n

\n
\n

Components available separately<\/strong><\/h3>\n\n\n\n

Flexible reordering \u2013 including calibrators and control solutions.<\/p>\n<\/div>\n\n\n\n

\n

More information about PEth<\/strong><\/a><\/h3>\n<\/div>\n\n\n\n
<\/div>\n<\/div>\n\n\n\n
<\/div>\n\n\n\n
\n
<\/div>\n\n\n\n

Technical Data & Specifications<\/h2>\n\n\n\n
\n
\n

Analytes<\/strong><\/h3>\n\n\n\n

PEth 16:0\/18:1 <\/strong>(main analyt)<\/p>\n\n\n\n

PEth<\/strong> 16:0\/18:2 <\/strong>(additional)<\/p>\n\n\n\n

Matrix: Human whole blood<\/strong><\/p>\n\n\n\n

Measurement principle: LC\u2011MS\/MS<\/strong><\/p>\n<\/div>\n\n\n\n

\n

Throughput & Cycle Times<\/strong><\/h3>\n\n\n\n

Chromatography: 3:00 min<\/strong><\/p>\n\n\n\n

Injection interval: 3:20 min<\/strong><\/p>\n\n\n\n

Kit size: 330 Assays<\/strong><\/p>\n<\/div>\n\n\n\n

\n

Calibration & QC<\/strong><\/h3>\n\n\n\n

Calibration: 7-point calibrators<\/strong><\/p>\n\n\n\n

Quality controls: 3\u2011point\u2011controls<\/strong><\/p>\n\n\n\n

Extended calibration up to 4000 ng\/mL<\/strong> (optional)<\/p>\n\n\n\n

All components are also available separately<\/strong>.<\/p>\n<\/div>\n<\/div>\n\n\n\n

\n
\n

Sample preparation<\/strong><\/h3>\n\n\n\n

Compatible with standard pipettes and common centrifuge technology<\/p>\n\n\n\n

Two-step protocol in 1.5 mL reaction tubes<\/p>\n\n\n\n

Simple, rapid sample preparation for routine laboratories<\/p>\n<\/div>\n\n\n\n

\n

Compatibility & Integration<\/strong><\/h3>\n\n\n\n

Detailed IFU\/method document available (upon request)<\/p>\n\n\n\n

Suitable for use on LC-MS\/MS systems with standard ESI sources<\/p>\n\n\n\n

Can be integrated into LIMS workflows<\/p>\n<\/div>\n<\/div>\n\n\n\n

<\/div>\n<\/div><\/div>\n\n\n\n
<\/div>\n\n\n\n

Performance data<\/h2>\n\n\n\n
\n
\n

PEth 16:0\/18:1<\/strong><\/h3>\n\n\n\n
Linearity<\/strong><\/td>4,9 – 6373,8 ng\/mL<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
Measuring range<\/strong><\/td><\/td><\/tr>
A371-011
A371-011 with A371-080
A371-011 with A371-082<\/td>		4,9 – 1000 ng\/mL
4,9 – 3000 ng\/mL
4,9 – 4000 ng\/mL<\/td><\/tr>
LOD<\/strong><\/td>2,1 ng\/mL<\/td><\/tr>
LOQ<\/strong><\/td>4,9 ng\/mL<\/td><\/tr>
Precision<\/strong><\/td>CV [%]; n=160<\/strong><\/td><\/tr>
Level 1
Level 2
Leve 3<\/td>		8%
5%
5%<\/td><\/tr>
Trueness<\/strong><\/td>abs BIAS [%]<\/strong><\/td><\/tr>
Arvecon 3\/25 A
Arvecon 3\/25 B<\/td>		5,5%
6,9%<\/td><\/tr><\/tbody><\/table><\/figure>\n<\/div>\n\n\n\n
\n

PEth 16:0\/18:2<\/strong><\/h3>\n\n\n\n
Linearity<\/strong><\/strong><\/td>4,1 – 6109,4 ng\/mL<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
Measuring range<\/strong><\/strong><\/td><\/td><\/tr>
A371-011
A371-011 with A371-080
A371-011 with A371-082<\/td>		4,1 – 1000 ng\/mL
4,1 – 3000 ng\/mL
4,1 – 4000 ng\/mL<\/td><\/tr>
LOD<\/strong><\/td>1,4 ng\/mL<\/td><\/tr>
LOQ<\/strong><\/td>4,1 ng\/mL<\/td><\/tr>
Precision<\/strong><\/td>CV [%]; n=160<\/strong><\/td><\/tr>
Level 1
Level 2
Leve 3<\/td>		6%
5%
5%<\/td><\/tr>
Trueness<\/strong><\/strong><\/td>abs BIAS [%]<\/strong><\/td><\/tr>
ACQ 724<\/td>5%<\/td><\/tr><\/tbody><\/table><\/figure>\n<\/div>\n<\/div>\n\n\n\n
\"\"<\/figure>\n\n\n\n
<\/div>\n\n\n\n
\n
<\/div>\n\n\n\n

Workflow<\/h2>\n\n\n\n
\n
\"\"<\/figure>\n<\/div><\/div>\n\n\n\n
<\/div>\n<\/div><\/div>\n\n\n\n
\n
<\/div>\n\n\n\n

Ordering information<\/h2>\n\n\n\n
\n
Ordering number<\/strong><\/td>Description<\/strong><\/td>Quantity\/Unit<\/strong><\/td><\/tr>
A371-001<\/td>Mobile Phase for PEth from whole blood<\/td>650 mL<\/td><\/tr>
A371-006<\/td>Optimization mix for PEth from whole blood<\/td>2 mL<\/td><\/tr>
A371-010<\/td>Precipitation solution with internal standard for PEth from whole blood<\/td>50 mL<\/td><\/tr>
W001-01<\/td>Washing solution 001<\/td>1000 mL<\/td><\/tr>
A371-011<\/td>Calibrator set \u2013 Level 0 \u2013 6 for PEth from whole blood<\/td>7 x 1 x 250 \u03bcL<\/td><\/tr>
A371-012<\/td>Control set \u2013 Level I \u2013 III for PEth from whole blood<\/td>3 x 2 x 250 \u03bcL<\/td><\/tr>
A371-090<\/td>HPLC column for PEth from whole blood<\/td>1 pcs<\/td><\/tr>
A371-091<\/td>HPLC column 2 for PEth from whole blood
(optional)<\/td>		1 pcs<\/td><\/tr>
A371-080<\/td>Calibrator 7 for PEth from whole blood
(optional)<\/td>		1 x 1 x 250 \u03bcL<\/td><\/tr>
A371-082<\/td>Calibrator 8 for PEth from whole blood
(optional)<\/td>		1 x 1 x 250 \u03bcL<\/td><\/tr>
A371-081<\/td>Control IV for PEth from whole blood
(optional)<\/td>		1 x 1 x 250 \u03bcL<\/td><\/tr><\/tbody><\/table><\/figure>\n<\/div><\/div>\n\n\n\n
<\/div>\n<\/div><\/div>\n\n\n\n
\n
<\/div>\n\n\n\n

Frequently Asked Questions<\/h2>\n\n\n\n
\n
\n

What is PEth?<\/h3>\n\n\n\n

Phosphatidylethanol (PEth) is a direct biomarker of alcohol consumption that forms in red blood cell membranes. Measuring it in whole blood allows for an assessment of long-term drinking patterns, unlike short-lived markers.<\/p>\n<\/div>\n\n\n\n

\n

Who is this test intended for?<\/h3>\n\n\n\n

For professional users in clinical and forensic laboratories where the concentration of PEth 16:0\/18:1 and PEth 16:0\/18:2 in whole blood is relevant.<\/p>\n<\/div>\n<\/div>\n\n\n\n

\n
\n

What results does the kit provide?<\/h3>\n\n\n\n

Quantitative results (LC-MS\/MS) for the PEth species 16:0\/18:1 and 16:0\/18:2, based on a 7-point calibration and accompanying 3-point controls.<\/p>\n<\/div>\n\n\n\n

\n

Can sample preparation be automated?<\/h3>\n\n\n\n

We are currently working on automating the sample preparation process. More information will follow.<\/p>\n<\/div>\n<\/div>\n\n\n\n

<\/div>\n<\/div><\/div>\n\n\n\n
<\/div>\n\n\n\n

Clinical background<\/h2>\n\n\n\n

PEth is primarily detected in red blood cells (RBCs), where it integrates into the phospholipid bilayer of the membrane. It is formed through the enzymatic reaction facilitated by phospholipase D, which catalyzes the conversion of phosphatidylcholine to PEth in the presence of ethanol. This process does not occur in the absence of alcohol, which is why PEth has gained prominence as a more reliable marker of alcohol consumption compared to other substances, such as breath alcohol tests or urine alcohol metabolites.<\/p>\n\n\n\n

Detection Window and Sensitivity<\/h3>\n\n\n\n

PEth\u2019s advantage lies in its longer detection window. It remains detectable for up to 2-3 weeks following heavy alcohol consumption, depending on the amount of alcohol consumed. Other markers such as blood ethanol or breath alcohol only provide information on recent consumption (within hours), while PEth levels continue to reflect alcohol use days after ingestion. This extended window makes PEth particularly useful in detecting alcohol use in chronic alcoholics or individuals undergoing alcohol treatment programs. Moreover, PEth levels correlate directly with the quantity of alcohol consumed, enabling clinicians to assess the extent of alcohol use.<\/p>\n\n\n\n

PEth as a Marker of Chronic Alcohol Consumption<\/h3>\n\n\n\n

Chronic alcohol consumption can lead to various health complications, including liver disease, cardiovascular problems, and neurological impairments. Monitoring alcohol intake is crucial in both the diagnosis and management of these conditions. PEth provides a more accurate measure of alcohol intake over time compared to other markers, such as gamma-glutamyltransferase (GGT) or mean corpuscular volume (MCV), which are often used but less specific. Clinical studies have shown that PEth is highly sensitive in detecting heavy drinking in both short- and long-term consumption scenarios, which is important for managing patients with alcohol-related disorders. A study by Viel and colleagues (2012) demonstrated that PEth was able to detect alcohol consumption in chronic drinkers, with high sensitivity and specificity. The study found that PEth was detectable in nearly 90% of subjects who consumed alcohol regularly, making it a more reliable indicator of alcohol use than traditional biomarkers.<\/p>\n\n\n\n

PEth in Alcohol Treatment Programs<\/h3>\n\n\n\n

In alcohol dependence and recovery programs, monitoring adherence to abstinence or reductions in alcohol consumption is essential. PEth testing has been integrated into several clinical treatment regimens, particularly in settings where long-term abstinence is crucial, such as rehabilitation centers. PEth testing allows clinicians to objectively assess whether a patient has relapsed or resumed alcohol consumption, providing valuable information for adjusting treatment plans. Research published by Helander et al. (2019) supports the use of PEth in detecting alcohol use in patients undergoing detoxification, showing that PEth testing can guide clinicians in modifying treatment strategies based on the patient\u2019s alcohol use.<\/p>\n\n\n\n

<\/div>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Why “PEth from whole blood”? Designed for medium to high routine throughput, clear decision-making criteria, and seamless integration into existing LC-MS\/MS workflows. LC\u2011MS\/MS\u2011Kit for 330 Assays Scalable for routine laboratories and projects with high sample volumes. Expanded range of analytes Quantification of PEth 16:0\/18:1 and PEth 16:0\/18:2. Easy sample preparation (1,5 mL tubes) Compatible with standard […]<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-product.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-1525","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nPEth LC-MS\/MS Kit from Whole Blood | IVD | ARCHImedline<\/title>\n<meta name=\"description\" content=\"ARCHImedline manufactures a high-quality IVDR approved PEth LC-MS\/MS kit for the quantitative determination of PEth 16:0\/18:1 and 16:0\/18:2 in whole blood.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.archimedline.com\/en\/peth-lc-msms-kit-whole-blood\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" 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